Description

4-(2-Amino-1-Hydroxyethyl)-1,2-Benzenediol Tetrakis(Trimethylsilyl)Deriv. is a key protected derivative of a catecholamine precursor, specifically designed for advanced synthetic chemistry applications. This compound is critical for researchers and manufacturers requiring precise control over reactivity and stability in sensitive multi-step syntheses. It is primarily utilized in pharmaceutical R&D for the synthesis of complex bioactive molecules, including neurotransmitters and their analogs.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of catecholamine-based active pharmaceutical ingredients (APIs) and complex drug candidates.
• Organic Synthesis Reagent: Used in advanced organic synthesis where the trimethylsilyl (TMS) protecting groups are essential for selective reactions on the amine and hydroxyl functionalities.
• Neurological Research: Serves as a protected precursor in the laboratory-scale preparation of neurotransmitters like dopamine, epinephrine, and norepinephrine for biochemical studies.
• Chemical Derivatization: Employed in analytical chemistry for the derivatization of sensitive compounds to improve their stability and detectability in chromatographic methods (e.g., GC, GC-MS).
• Process Development: Used in the development and scale-up of synthetic routes for high-value fine chemicals and specialty materials.

Basic Information

Product Name	4-(2-Amino-1-Hydroxyethyl)-1,2-Benzenediol Tetrakis(Trimethylsilyl)Deriv.
CAS No.	56145-09-6
Molecular Formula	C20H43NO4Si4
Molecular Weight	497.92 g/mol
Synonyms	1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, tetrakis(trimethylsilyl) derivative; Tetrakis(trimethylsilyl) Derivative of 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; TMS-Protected Dopamine Precursor; N,O-TMS Derivative of Noradrenaline; 3,4-Bis(trimethylsilyloxy)phenethylamine N-TMS Derivative; Fully Silylated Norepinephrine Intermediate; CAS 56145-09-6
EINECS	Contact for details

Quality Control

Our 4-(2-Amino-1-Hydroxyethyl)-1,2-Benzenediol Tetrakis(Trimethylsilyl)Deriv. is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.