Description

(Trimethylsilyl)Malonic Acid Bis(Trimethylsilyl) Ester is a highly versatile organosilicon reagent, primarily valued for its role as a protected malonate synthon in complex organic synthesis. Its key function is to introduce a malonate moiety under mild conditions while offering excellent stability and solubility in non-polar organic media. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, particularly for constructing complex molecular frameworks, heterocycles, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the preparation of β-keto esters, carboxylic acids, and other malonate-derived structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and plant growth regulators that require malonate-based backbones.
• Advanced Material Precursor: Serves as a monomer or modifying agent in the development of specialty polymers, silicones, and functionalized surfaces.
• Organic Synthesis Reagent: Employed in C-C bond-forming reactions, such as alkylations and Michael additions, under mild, non-aqueous conditions.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups effectively protect the reactive malonic acid functionality, allowing for selective transformations elsewhere in the molecule.
• Laboratory Research & Development: A valuable tool for medicinal chemistry and process development in academic and industrial R&D settings.

Basic Information

Product Name	(Trimethylsilyl)Malonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-48-0
Molecular Formula	C12H28O4Si3
Molecular Weight	320.60 g/mol
Synonyms	Bis(trimethylsilyl) (Trimethylsilyl)malonate; Malonic Acid, (Trimethylsilyl)-, Bis(trimethylsilyl) Ester; 2-(Trimethylsilyl)malonic Acid Bis(trimethylsilyl) Ester; (Trimethylsilyl)malonic Acid Bis-O-(trimethylsilyl) Ester; TMS-Malonic Acid Bis-TMS Ester; 1,3-Bis(trimethylsilyl) 2-(trimethylsilyl)propanedioate
EINECS	Contact for details

Quality Control

Our (Trimethylsilyl)Malonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical and fine chemical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition upon exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.