Description

Chroman-6-Carbonyl Chloride is a key reactive intermediate in organic synthesis, specifically an acid chloride derivative of chroman-6-carboxylic acid. This compound is valued for its role in introducing the chroman moiety into more complex molecular architectures via amide or ester bond formation. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate the chroman scaffold for enhanced biological activity.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and functional materials where the chroman structure imparts specific optical or chemical properties.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies and the exploration of new chemical spaces in medicinal chemistry.
• Peptide Mimetic & Bioconjugation: Facilitates the coupling of chroman-based groups to peptides or other biomolecules, useful in creating probes or modifying biomaterial properties.

Basic Information

Product Name	Chroman-6-Carbonyl Chloride
CAS No.	55746-03-7
Molecular Formula	C10H7ClO2
Molecular Weight	194.61 g/mol
Synonyms	6-Chromancarbonyl chloride; 3,4-Dihydro-2H-1-benzopyran-6-carbonyl chloride; 2H-1-Benzopyran-6-carbonyl chloride, 3,4-dihydro-; Chroman-6-carboxylic acid chloride; 6-Carboxychroman chloride; 3,4-Dihydro-2H-chromene-6-carbonyl chloride
EINECS	Contact for details

Quality Control

Our Chroman-6-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.