Description

2,3-Dihydro-1-Benzofuran-5-Carbonyl Chloride is a versatile and highly reactive organic intermediate, specifically an acid chloride derivative of the benzofuran scaffold. This compound is a critical building block in synthetic organic chemistry, enabling the efficient introduction of the 2,3-dihydrobenzofuran-5-carbonyl moiety into target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate the benzofuran structure for enhanced bioactivity.
• Material Science Research: Serves as a precursor for creating novel polymers, liquid crystals, or organic electronic materials with specific optical or electronic properties.
• Peptide Mimetics & Bioconjugation: The reactive acyl chloride group facilitates amide bond formation, useful in creating peptide analogs or for labeling biomolecules.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.
• Academic & Contract Research: Essential reagent for methodological development and synthetic route exploration in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	2,3-Dihydro-1-Benzofuran-5-Carbonyl Chloride
CAS No.	55745-71-6
Molecular Formula	C10H7ClO2
Molecular Weight	194.61 g/mol
Synonyms	5-Carboxybenzofuran-2,3-dihydro chloride; 2,3-Dihydrobenzofuran-5-carbonyl chloride; 2,3-Dihydro-5-benzofurancarbonyl chloride; 5-Chlorocarbonyl-2,3-dihydrobenzofuran; Benzofuran-5-carbonyl chloride, 2,3-dihydro-; 5-(Chloroformyl)-2,3-dihydro-1-benzofuran
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-1-Benzofuran-5-Carbonyl Chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) principles where applicable, and our quality system supports compliance with global regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.