Description

1-Methyl-6-Thioguanosine is a chemically modified nucleoside analog of guanosine, featuring a methyl group at the 1-position and a thio substitution at the 6-position. This structural modification makes it a valuable intermediate and reference standard in advanced pharmaceutical research and development, particularly for investigating nucleoside metabolism and designing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of antiviral drugs, anticancer compounds, and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to purine metabolism and nucleoside processing.
• Proteomics & Molecular Biology: Employed in the development of probes and tools for studying RNA modification and function.
• Antiviral Drug Development: Investigated for its potential incorporation into oligonucleotide analogs targeting viral replication.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	1-Methyl-6-Thioguanosine
CAS No.	55727-08-7
Molecular Formula	C11H15N5O4S
Molecular Weight	313.33 g/mol
Synonyms	6-Thio-1-methylguanosine; 1-Methyl-6-thioguanosine; 1-Methyl-6-mercaptoguanosine; 1-Methylguanosine-6-thiol; 6-Mercapto-1-methylguanosine; NSC 401005; 1-Me-6-TG; 1-Methyl-6-thio-Guo
EINECS	Contact for details

Quality Control

Our 1-Methyl-6-Thioguanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.