Description

N(4)-Oleoyl Cytarabine is a lipophilic prodrug derivative of the nucleoside analog cytarabine, designed to enhance cellular uptake and bioavailability. This chemical modification is crucial for improving the therapeutic efficacy and delivery profile of the parent compound in advanced pharmaceutical formulations. It is primarily required by research institutions and pharmaceutical developers engaged in oncology drug discovery, specifically for creating novel chemotherapeutic agents and targeted delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation, lipid-conjugated anticancer drugs.
• Oncology Research: Used in preclinical studies to investigate improved drug delivery mechanisms for leukemia and other cancers.
• Prodrug Development: Essential for formulating prodrugs with enhanced membrane permeability and sustained release profiles.
• Lipid Nanoparticle (LNP) Formulation: A potential component in the development of advanced LNP-based delivery systems for nucleic acid analogs.
• Bioconjugation Studies: Employed in research focusing on coupling active pharmaceutical ingredients with fatty acids to alter pharmacokinetics.

Basic Information

Product Name	N(4)-Oleoyl Cytarabine
CAS No.	55726-49-3
Molecular Formula	C33H55N3O6
Molecular Weight	589.81 g/mol
Synonyms	1-β-D-Arabinofuranosylcytosine 4'-N-oleoyl ester; Cytarabine Oleate; Cytarabine 4-N-oleoyl derivative; Ara-C 4-Oleoyl ester; N4-Oleoyl-1-β-D-arabinofuranosylcytosine; Oleoyl Cytarabine; N4-Oleoylcytarabine
EINECS	Contact for details

Quality Control

Our N(4)-Oleoyl Cytarabine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.