Description

3α,4α-Epoxy-2α-Methyl-5α-Cholestane is a high-purity, steroidal epoxide derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and synthetic intermediate for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in steroid chemistry, medicinal chemistry, and the synthesis of complex natural products. The compound's defined stereochemistry and reactive epoxide functionality make it a valuable scaffold for constructing more elaborate molecular architectures.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the multi-step synthesis of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new drug candidates targeting hormone receptors or metabolic pathways.
• Steroid Derivative Synthesis: Essential for the preparation of modified cholestane derivatives with potential biological activity for biochemical screening.
• Organic Synthesis Reagent: Employed as a chiral epoxide reagent in stereoselective ring-opening reactions to introduce the steroidal backbone into complex molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and research laboratories.
• Biochemical Research: Used in studies investigating cholesterol metabolism, membrane biophysics, and the interaction of sterols with proteins.

Basic Information

Product Name	3α,4α-Epoxy-2α-Methyl-5α-Cholestane
CAS No.	55724-43-1
Molecular Formula	C₂₈H₄₈O
Molecular Weight	400.68 g/mol
Synonyms	2α-Methyl-3α,4α-epoxy-5α-cholestane; (3α,4α)-2α-Methyl-5α-cholestane oxide; 5α-Cholestane-2α-methyl-3α,4α-epoxide; 3α,4α-Epoxy-2α-methylcholestane; 2-Methyl-3,4-epoxycholestane; Epoxymethylcholestane; Cholestane epoxide derivative
EINECS	Contact for details

Quality Control

Our 3α,4α-Epoxy-2α-Methyl-5α-Cholestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity, well-characterized synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be stored away from direct light. As it is easily oxidized, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.