Description

L-Asparagine, N,N2-Bis(Trimethylsilyl)-, Trimethylsilyl Ester is a specialized organosilicon derivative of the amino acid L-asparagine, designed for advanced synthetic applications. This compound is a critical reagent in organic synthesis, particularly for protecting sensitive functional groups and facilitating complex peptide and nucleoside modifications. It is primarily utilized by research and development laboratories in the pharmaceutical, agrochemical, and biotechnology sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, peptides, and nucleotide analogs.
• Amino Acid Protection: Used as a protecting group reagent for the amino and carboxyl functions of asparagine, enabling selective reactions in multi-step syntheses.
• Derivatization Agent: Employed in gas chromatography (GC) and mass spectrometry (MS) for the derivatization of amino acids to enhance volatility and detection.
• Organic Synthesis Reagent: Facilitates silylation reactions in the preparation of silyl esters and amides for various research and industrial chemical processes.
• Bioconjugate Chemistry: Applied in the modification of biomolecules for drug delivery systems and diagnostic probe development.
• Agrochemical Research: Used in the R&D of novel pesticides and plant growth regulators requiring advanced amino acid chemistry.

Basic Information

Product Name	L-Asparagine, N,N2-Bis(Trimethylsilyl)-, Trimethylsilyl Ester
CAS No.	55649-62-2
Molecular Formula	C15H36N2O3Si3
Molecular Weight	388.73 g/mol
Synonyms	N,N-Bis(trimethylsilyl)-L-asparagine trimethylsilyl ester; L-Asparagine, N,N-bis(trimethylsilyl)-, trimethylsilyl ester; Trimethylsilyl N,N-bis(trimethylsilyl)-L-asparaginate; O-Trimethylsilyl-N,N-bis(trimethylsilyl)-L-asparagine; TMS-Asparagine(TMS)2; Fully silylated L-asparagine; L-Asparagine TMS derivative
EINECS	Contact for details

Quality Control

Our L-Asparagine, N,N2-Bis(Trimethylsilyl)-, Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.