Description

5-Iodo-1-(2-Fluoro-2-Deoxyribofuranosyl)Uracil is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of nucleoside-based therapeutics. The high-purity grade of this material ensures reliable and reproducible results in sensitive synthetic and biological applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced antiviral drugs, particularly those active against herpesviruses and other DNA viruses.
• Antiviral Agent Research: Used as a reference standard and active scaffold in the discovery and development of new nucleoside analog therapeutics.
• Biochemical Research: Employed in enzymatic studies to investigate the mechanisms of viral replication and polymerase inhibition.
• Radiopharmaceutical Precursor: Serves as a starting material for the synthesis of iodine-123 or iodine-131 labeled compounds for diagnostic imaging or therapy.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency and selectivity of fluorinated nucleosides.
• Process Development: Acts as a critical intermediate in scaling up the production of target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5-Iodo-1-(2-Fluoro-2-Deoxyribofuranosyl)Uracil
CAS No.	55612-21-0
Molecular Formula	C9H10FIN2O5
Molecular Weight	372.09 g/mol
Synonyms	5-Iodo-2'-Fluoro-2'-deoxyuridine; 5-Iodo-1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)uracil; 5-Iodo-2'-F-2'-dUrd; 2'-Fluoro-5-iodo-2'-deoxyuridine; 5-Iodo-1-(2-fluoro-2-deoxy-β-D-ribofuranosyl)uracil; FIURD; 5-I-2'-F-dU
EINECS	Contact for details

Quality Control

Our 5-Iodo-1-(2-Fluoro-2-Deoxyribofuranosyl)Uracil is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of our global customer base in advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.