Description

5-Bromo-2'-Chloro-2'-Deoxyuridine is a halogenated nucleoside analog, a crucial building block in medicinal chemistry and biochemical research. This compound is valued for its role as a key intermediate in the synthesis of antiviral and anticancer agents, particularly those targeting viral DNA polymerases. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidine kinase and DNA polymerase enzymes.
• Antiviral Agent Development: Serves as a core structure for developing compounds active against herpesviruses and other DNA viruses.
• Radiopharmaceuticals: Potential use as a precursor for radioiodinated or radiobrominated compounds used in diagnostic imaging.
• Molecular Biology: Can be incorporated into oligonucleotides to study DNA-protein interactions or to create modified probes.
• Chemical Biology Tool: Employed to investigate cell proliferation and DNA synthesis mechanisms in experimental models.

Basic Information

Product Name	5-Bromo-2'-Chloro-2'-Deoxyuridine
CAS No.	55612-19-6
Molecular Formula	C9H10BrClN2O5
Molecular Weight	341.54 g/mol
Synonyms	5-Br-2'-Cl-2'-dU; 5-Bromo-2'-chloro-2'-deoxyuridine; 2'-Chloro-5-bromo-2'-deoxyuridine; 1-((2R,4S,5R)-4-Chloro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-bromopyrimidine-2,4(1H,3H)-dione; BCDU; BrCldU; 5-Bromo-2'-chloro-2'-deoxyuridine (BCDU)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2'-Chloro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.