Description

5-Chloro-1-(2'-Fluoro-2'-Deoxyribofuranosyl)Uracil is a fluorinated nucleoside analog, a key intermediate in the synthesis of antiviral and anticancer pharmaceuticals. This compound matters for its role in developing targeted therapies, particularly as a precursor for modified nucleosides used in medicinal chemistry and biochemical research. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on antiviral drug discovery and nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating enzyme mechanisms, DNA/RNA synthesis inhibition, and metabolic pathways.
• Antiviral Drug Development: Serves as a precursor for compounds targeting viral polymerases and reverse transcriptases.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Nucleotide Chemistry: Used in the synthesis of modified oligonucleotides for diagnostic and therapeutic applications.

Basic Information

Product Name	5-Chloro-1-(2'-Fluoro-2'-Deoxyribofuranosyl)Uracil
CAS No.	55612-15-2
Molecular Formula	C9H10ClFN2O5
Molecular Weight	280.64 g/mol
Synonyms	5-Chloro-2'-deoxy-2'-fluorouridine; 2'-Deoxy-2'-fluoro-5-chlorouridine; 5-Chloro-1-[(2R,3R,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5-Chloro-2'-fluoro-2'-deoxyuridine; FdUrd-Cl; 5-Cl-2'-F-2'-dUrd; 5-Chloro-1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)uracil
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-(2'-Fluoro-2'-Deoxyribofuranosyl)Uracil is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.