Description

5'-o-Trityl-2'-Deoxy-β-D-Lyxofuranosylthymine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical key building block in the production of modified DNA strands, enabling advanced research and therapeutic development. It is primarily required by pharmaceutical R&D laboratories and biotech companies focused on antisense technology, diagnostics, and novel therapeutic modalities.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): As a key monomer for the controlled assembly of DNA sequences with specific modifications.
• Antisense Oligonucleotide (ASO) Development: For the research and production of therapeutic oligonucleotides targeting genetic diseases.
• Diagnostic Probe Synthesis: Used in creating labeled probes for genetic testing and molecular diagnostics.
• Research on Nucleic Acid Chemistry: A vital reagent for studying structure-activity relationships and developing novel nucleoside analogs.
• siRNA and miRNA Synthesis: As a precursor in the synthesis of RNAi-based therapeutic agents.
• Pharmaceutical Intermediate: Serves as a protected intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	5'-o-Trityl-2'-Deoxy-β-D-Lyxofuranosylthymine
CAS No.	55612-11-8
Molecular Formula	C29H28N2O6
Molecular Weight	500.54 g/mol
Synonyms	5'-O-(Triphenylmethyl)-2'-deoxy-β-D-lyxofuranosylthymine; 5'-O-Tritylthymidine 2'-deoxy-β-D-lyxofuranoside; N1-[(2R,4S,5R)-4-Hydroxy-5-[(triphenylmethoxy)methyl]tetrahydrofuran-2-yl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-5'-O-trityl-β-D-lyxothymidine; Protected Lyxothymidine; Tritylated Lyxofuranosylthymine
EINECS	Contact for details

Quality Control

Our 5'-o-Trityl-2'-Deoxy-β-D-Lyxofuranosylthymine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity and purity verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.