Description

2,4(1H,3H)-Pyrimidinedione, 1-[(2S)-2,3-Dihydroxypropyl]-5-Methyl- is a high-purity, chiral pyrimidine derivative of significant interest in advanced organic synthesis. This compound matters for its role as a sophisticated building block in the development of nucleoside analogs and other biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and other therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA/RNA synthesis pathways.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic systems and modified nucleosides due to its reactive pyrimidine core and chiral dihydroxypropyl side chain.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Item	Details
Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[(2S)-2,3-Dihydroxypropyl]-5-Methyl-
CAS No.	55559-64-3
Molecular Formula	C8H12N2O4
Molecular Weight	200.19 g/mol
Synonyms	5-Methyl-1-[(2S)-2,3-dihydroxypropyl]pyrimidine-2,4(1H,3H)-dione; (S)-5-Methyl-1-(2,3-dihydroxypropyl)uracil; 1-[(2S)-2,3-Dihydroxypropyl]-5-methyluracil; 5-Methyl-1-[(S)-2,3-dihydroxypropyl]uracil; L-5-Methyl-1-(2,3-dihydroxypropyl)uracil; 5-Methyl-DHU (dihydroxypropyl uracil); 55559-64-3; Chiral dihydroxypropyl thymine analog
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione, 1-[(2S)-2,3-Dihydroxypropyl]-5-Methyl- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.