Description

2-Methoxy-2-Phenylacetic Acid Trimethylsilyl Ester is a specialized organosilicon reagent primarily used as a key protected intermediate in advanced organic synthesis. This compound matters for its role in facilitating complex chemical transformations, particularly in the synthesis of chiral molecules and active pharmaceutical ingredients (APIs), where protecting group chemistry is critical. It is needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for building complex molecular architectures with high precision.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of chiral drugs and active pharmaceutical ingredients (APIs).
• Chiral Synthesis: Used in asymmetric synthesis and the preparation of enantiomerically pure compounds where the methoxy-phenylacetic acid moiety is required.
• Protecting Group Strategy: The trimethylsilyl (TMS) ester group serves as a protective group for carboxylic acids during complex synthetic sequences, which can be selectively removed under mild conditions.
• Peptidomimetics & Bioactive Molecule Research: Employed in the research and development of peptide analogs and other bioactive molecules.
• Agrochemical Synthesis: Intermediate in the production of certain herbicides and plant growth regulators with specific stereochemistry.
• Material Science Precursor: Potential monomer or modifying agent in the synthesis of specialized polymers and advanced materials.

Basic Information

Product Name	2-Methoxy-2-Phenylacetic Acid Trimethylsilyl Ester
CAS No.	55557-19-2
Molecular Formula	C₁₂H₁₈O₃Si
Molecular Weight	238.35 g/mol
Synonyms	Trimethylsilyl 2-Methoxy-2-phenylacetate; (2-Methoxy-2-phenylacetic acid) trimethylsilyl ester; α-Methoxyphenylacetic Acid Trimethylsilyl Ester; O-Trimethylsilyl O-Methyl Mandelate; TMS Ester of 2-Methoxy-2-phenylacetic Acid; Mandelic Acid, 2-Methoxy-, Trimethylsilyl Ester; Atrolactic Acid, α-Methoxy-, Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our 2-Methoxy-2-Phenylacetic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.