Description

2-Methyl-2-[(Trimethylsilyl)Oxy]Butyric Acid Trimethylsilyl Ester is a specialized organosilicon compound, a fully silylated derivative of 2-hydroxy-2-methylbutyric acid, which serves as a versatile protecting group reagent and synthetic intermediate in advanced organic synthesis. Its core value lies in its ability to efficiently protect hydroxyl and carboxyl functionalities, enabling complex multi-step reactions with high selectivity and yield. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and novel materials.

Application

• Pharmaceutical Synthesis: Key intermediate and protecting group reagent in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the research and production of advanced pesticides, herbicides, and plant growth regulators requiring selective protection strategies.
• Fine Chemical Manufacturing: Employed as a building block for synthesizing specialty chemicals, flavors, fragrances, and advanced polymer precursors.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, enabling new routes for C-C and C-O bond formation.
• Material Science: Potential precursor for silicon-containing hybrid materials and surface modification agents.
• Process Chemistry: Used to improve reaction efficiency and purity in scale-up processes for high-value chemical products.

Basic Information

Product Name	2-Methyl-2-[(Trimethylsilyl)Oxy]Butyric Acid Trimethylsilyl Ester
CAS No.	55557-18-1
Molecular Formula	C11H26O3Si2
Molecular Weight	262.50 g/mol
Synonyms	2-Hydroxy-2-methylbutyric Acid Bis(trimethylsilyl) Ester; α-Hydroxyisovaleric Acid Bis(trimethylsilyl) Ether; Bis(trimethylsilyl) 2-Hydroxy-2-methylbutyrate; 2-Methyl-2-(trimethylsiloxy)butyric Acid Trimethylsilyl Ester; TMS Ester of 2-Hydroxy-2-methylbutyric Acid; 2-(Trimethylsiloxy)-2-methylbutyric Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-2-[(Trimethylsilyl)Oxy]Butyric Acid Trimethylsilyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to verify identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality frameworks for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%
Density (at 20°C)	~0.88 g/mL
Refractive Index (n20D)	~1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.