Description

2-Methyl-3-[(Trimethylsilyl)Oxy]Butanoic Acid Trimethylsilyl Ester is a specialized organosilicon-protected derivative of a branched-chain carboxylic acid, offering enhanced stability and solubility for advanced synthetic applications. This compound is valued for its role as a key synthetic intermediate and protecting group reagent in the preparation of complex organic molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing chiral centers and sensitive molecular frameworks.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protected hydroxy acid functionalities.
• Chiral Synthesis: Used in asymmetric synthesis and the preparation of enantiomerically pure compounds due to its defined stereochemistry at the 2-position.
• Protecting Group Chemistry: The trimethylsilyl (TMS) groups serve as protective agents for both the carboxylic acid and alcohol functionalities, allowing selective reactions elsewhere on the molecule.
• Agrochemical Research: Employed in the development and research of novel herbicides, fungicides, and plant growth regulators.
• Advanced Material Precursor: Acts as a monomer or modifying agent in the synthesis of specialized polymers and silicon-containing hybrid materials.
• Process Chemistry & Scale-Up: Suitable for process optimization and kilogram-scale production in GMP or non-GMP environments for clinical trial material manufacturing.

Basic Information

Product Name	2-Methyl-3-[(Trimethylsilyl)Oxy]Butanoic Acid Trimethylsilyl Ester
CAS No.	55557-17-0
Molecular Formula	C11H26O3Si2
Molecular Weight	262.50 g/mol
Synonyms	2-Methyl-3-(trimethylsiloxy)butanoic acid trimethylsilyl ester; Butanoic acid, 2-methyl-3-[(trimethylsilyl)oxy]-, trimethylsilyl ester; 3-(Trimethylsiloxy)-2-methylbutyric acid TMS ester; TMS ester of 2-methyl-3-(trimethylsiloxy)butanoic acid; Bis(trimethylsilyl) 2-methyl-3-hydroxybutyrate; 2-Methyl-3-trimethylsiloxybutyric acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-3-[(Trimethylsilyl)Oxy]Butanoic Acid Trimethylsilyl Ester adheres to stringent in-process controls and final release specifications to ensure batch-to-batch consistency and high purity. Quality is verified through analytical techniques including GC, HPLC, NMR, and Karl Fischer titration. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development under quality agreements and can supply material suitable for use in regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 3.0%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.