Description

2-Methylbutyric Acid Trimethylsilyl Ester is a specialized organosilicon derivative of 2-methylbutyric acid, valued for its role as a versatile protecting group and derivatization agent in synthetic organic chemistry. Its primary commercial value lies in enhancing the volatility and thermal stability of carboxylic acids for analytical techniques like gas chromatography, facilitating precise compound identification and quantification. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fragrance industries, where precise molecular manipulation and analysis are critical.

Application

• Analytical Chemistry Derivatization: Used to silylate carboxylic acids for improved detection and separation in Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Pharmaceutical Intermediate: Serves as a key protecting group reagent in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), safeguarding carboxylic acid functionalities during reactions.
• Agrochemical Synthesis: Employed in the production of advanced pesticides and herbicides where the trimethylsilyl ester group is used to control reactivity and improve product stability.
• Flavor and Fragrance Industry: Acts as a precursor or intermediate in the synthesis of specific ester compounds that contribute to complex aroma and flavor profiles.
• Organic Synthesis Research: A valuable tool in academic and industrial R&D labs for constructing complex molecular architectures, particularly in natural product synthesis.
• Material Science: Potential use as a surface modifying agent or as a monomer in the synthesis of specialized silicon-containing polymers.

Basic Information

Product Name	2-Methylbutyric Acid Trimethylsilyl Ester
CAS No.	55557-14-7
Molecular Formula	C8H18O2Si
Molecular Weight	174.31 g/mol
Synonyms	Trimethylsilyl 2-methylbutyrate; 2-Methylbutanoic Acid Trimethylsilyl Ester; TMS 2-Methylbutyrate; (Trimethylsilyl) 2-methylbutanoate; 2-Methylbutyric Acid TMS Ester; Butanoic acid, 2-methyl-, trimethylsilyl ester; α-Methylbutyric Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our 2-Methylbutyric Acid Trimethylsilyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to confirm identity, potency, and moisture content. Certificates of Analysis (COA) detailing all specification parameters are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.