Description

2-Thiophenecarboxylic Acid, Trimethylsilyl Ester is a high-purity organosilicon reagent featuring a protected carboxylic acid group on a thiophene heterocycle. This compound is a critical building block in advanced organic synthesis, offering enhanced stability and reactivity for the introduction of the 2-thiophenecarboxyl moiety. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for constructing thiophene-containing drug candidates, particularly in antiviral, anti-inflammatory, and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the thiophene ring system imparts specific biological activity.
• Material Science & Organic Electronics: Serves as a precursor for monomers and functionalized molecules used in conductive polymers, organic semiconductors, and OLED materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings for carbon-carbon bond formation.
• Protecting Group Strategy: The trimethylsilyl ester group provides a stable, yet cleavable, protection for the carboxylic acid during multi-step syntheses.
• Chemical Research & Development: Essential reagent in academic and industrial R&D labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, Trimethylsilyl Ester
CAS No.	55557-11-4
Molecular Formula	C9H14O2SSi
Molecular Weight	214.36 g/mol
Synonyms	Trimethylsilyl 2-thiophenecarboxylate; 2-Thiophenecarboxylic Acid TMS Ester; TMS 2-Thiophenecarboxylate; 2-(Trimethylsilyloxycarbonyl)thiophene; Thiophene-2-carboxylic Acid Trimethylsilyl Ester; 2-Carboxythiophene Trimethylsilyl Ester; α-Thiophenecarboxylic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and identity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all relevant specifications. Our quality commitment supports applications requiring research and process development grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.