Description

N,n-Dimethyl-1-Trimethylsilyl-2'-O,3'-O,5'-o-Tris(Trimethylsilyl)Guanosine is a highly specialized, fully protected guanosine derivative, extensively used as a critical synthetic intermediate in advanced organic and nucleoside chemistry. Its value lies in providing a robust, multi-silylated scaffold that protects reactive hydroxyl and amine groups, enabling precise and high-yield reactions in complex synthesis pathways. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of modified oligonucleotides, prodrugs, and novel antiviral or anticancer agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel nucleoside analogs with potential therapeutic activity.
• Oligonucleotide Synthesis: Used in the preparation of protected phosphoramidites for solid-phase synthesis of DNA/RNA sequences.
• Prodrug Development: Serves as a precursor for creating lipophilic prodrugs of antiviral or anticancer nucleosides to enhance bioavailability.
• Chemical Biology Research: Employed in the study of RNA structure, function, and in the development of labeled nucleosides for diagnostic probes.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Product Name	N,n-Dimethyl-1-Trimethylsilyl-2'-O,3'-O,5'-o-Tris(Trimethylsilyl)Guanosine
CAS No.	55556-84-8
Molecular Formula	C₂₄H₅₃N₅O₅Si₄
Molecular Weight	612.0 g/mol
Synonyms	1,2',3',5'-O-Tetrakis(trimethylsilyl)-N,N-dimethylguanosine; 2',3',5'-O-Tris(trimethylsilyl)-N,N-dimethyl-1-(trimethylsilyl)guanosine; N,N-Dimethyl-1-(trimethylsilyl)-2',3',5'-O-tris(trimethylsilyl)guanosine; Fully Silylated N,N-Dimethylguanosine; Protected Guanosine Derivative; TMS-Guanosine Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP manufacturing needs with traceable documentation and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.