Description

Trimethylsilyl-D(+)Mannose is a protected derivative of D-mannose, a fundamental monosaccharide, where the hydroxyl groups are silylated to enhance stability and alter reactivity. This modification is critical for synthetic organic and carbohydrate chemistry, enabling precise control over glycosylation reactions and protecting group strategies. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutics, diagnostics, and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex glycoconjugates, antiviral agents, and carbohydrate-based drugs.
• Glycosylation Reactions: Used as a glycosyl donor or acceptor in controlled oligosaccharide and glycopeptide synthesis.
• Chemical Derivatization: Employed to increase the volatility and thermal stability of mannose for analytical techniques like Gas Chromatography-Mass Spectrometry (GC-MS).
• Protecting Group Chemistry: The trimethylsilyl (TMS) groups protect reactive hydroxyls during multi-step synthetic sequences, allowing for selective deprotection.
• Bioconjugation: Facilitates the site-specific attachment of carbohydrate moieties to proteins, peptides, or other biomolecules.
• Research & Development: A valuable tool for academic and industrial R&D in carbohydrate chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Trimethylsilyl-D(+)Mannose
CAS No.	55529-69-6
Molecular Formula	C15H36O6Si4
Molecular Weight	440.81 g/mol
Synonyms	D-Mannose, O-trimethylsilyl derivative; Per-O-trimethylsilyl-D-mannose; D-Mannose per(trimethylsilyl) ether; 1,2,3,4,5,6-Hexa-O-trimethylsilyl-D-mannose; D-Mannose, hexakis(trimethylsilyl) ether; TMS-D-Mannose; Hexa-O-trimethylsilyl-D-mannopyranose; D-Mannopyranose, hexakis-O-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Our Trimethylsilyl-D(+)Mannose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide full traceability and Certificates of Analysis (COA) with every shipment to support your quality assurance and regulatory compliance needs in research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.