Description

5-Vinyl-2'-Deoxyuridine is a chemically modified nucleoside analog of deoxyuridine, featuring a vinyl substituent at the 5-position of the uracil base. This structural modification makes it a valuable synthetic intermediate and building block in medicinal chemistry and life science research. It is primarily utilized by pharmaceutical R&D departments and biotechnology companies engaged in the development of novel therapeutic agents and diagnostic probes. The compound's unique structure allows for further functionalization, enabling its incorporation into more complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Bioconjugation & Probe Development: The vinyl group serves as a reactive handle for click chemistry, facilitating the creation of fluorescent or affinity-labeled probes for molecular biology.
• Antisense Oligonucleotide (ASO) Research: Used in the development of modified oligonucleotides to enhance stability and binding affinity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving thymidylate synthase and other nucleotide-processing enzymes.
• Precision Medicine Tool Development: Incorporated into diagnostic platforms and targeted therapeutic constructs.

Basic Information

Product Name	5-Vinyl-2'-Deoxyuridine
CAS No.	55520-67-7
Molecular Formula	C11H14N2O5
Molecular Weight	254.24 g/mol
Synonyms	5-Vinyl-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-vinylpyrimidine-2,4-dione; 2'-Deoxy-5-vinyluridine; 5-Ethenyl-2'-deoxyuridine; dVDU; 5-Vinyl-dUrd; 5-Vinyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Vinyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening and allowed to reach room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.