Description

5-Vinyl-Uridine is a modified nucleoside analog of uridine, featuring a vinyl group at the 5-position of the pyrimidine ring. This structural modification makes it a valuable building block for the synthesis of oligonucleotides and other biomolecules, enabling advanced research and development in life sciences. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in antisense therapy, RNA research, and the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified RNA and DNA strands, particularly for research into antisense oligonucleotides and siRNA.
• Bioconjugation & Probe Development: The vinyl group serves as a reactive handle for click chemistry (e.g., thiol-ene reactions) to attach fluorescent dyes, affinity tags, or other functional moieties for diagnostic probes.
• Medicinal Chemistry & Drug Discovery: Used as a precursor in the development of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Employed in studies of RNA structure, function, and metabolism to investigate enzyme mechanisms and nucleic acid interactions.
• Cross-linking Studies: The reactive vinyl group can be utilized to create cross-linked nucleic acid structures for studying tertiary folding and biomolecular complexes.

Basic Information

Product Name	5-Vinyl-Uridine
CAS No.	55520-64-4
Molecular Formula	C11H14N2O6
Molecular Weight	270.24 g/mol
Synonyms	5-Vinyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-vinylpyrimidine-2,4-dione; Uridine, 5-vinyl-; 5-Vinyl-1-β-D-ribofuranosyluracil; 5-Ethenyluridine
EINECS	Contact for details

Quality Control

Our 5-Vinyl-Uridine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.