Description

[(Pregn-5-Ene-3α,20-Diyl)Bisoxy]Bis(Trimethylsilane) is a high-purity, protected steroid derivative used as a critical synthetic intermediate in advanced organic chemistry. This compound matters for its role in enabling complex, multi-step syntheses where selective protection of hydroxyl groups is required, ensuring reaction fidelity and high yields. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel steroid-based therapeutics, including hormone modulators and anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex molecular architectures, particularly in medicinal chemistry programs.
• Hormone Analog Development: Serves as a precursor in the development of progesterone and corticosteroid analogs for therapeutic applications.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of specialty steroids.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	[(Pregn-5-Ene-3α,20-Diyl)Bisoxy]Bis(Trimethylsilane)
CAS No.	55515-25-8
Molecular Formula	C29H54O2Si2
Molecular Weight	490.91 g/mol
Synonyms	3α,20-Bis(trimethylsilyloxy)pregn-5-ene; Pregn-5-ene-3α,20-diol bis(trimethylsilyl) ether; 3α,20-Bis-O-(trimethylsilyl)pregn-5-en-3α,20-diol; 3,20-Bis(trimethylsiloxy)pregn-5-ene; 5-Pregnene-3α,20α-diol bis(trimethylsilyl ether); TMS ether of pregnenolone diol; Pregnenolone 3,20-bis(TMS) ether
EINECS	Contact for details

Quality Control

Our [(Pregn-5-Ene-3α,20-Diyl)Bisoxy]Bis(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.