Description

2,3,4,5,6-Pentafluorophenoxyacetyl Chloride is a highly reactive and versatile fluorinated building block used in advanced organic synthesis. Its core value lies in its ability to introduce the pentafluorophenoxyacetyl group, a key moiety for constructing complex molecules with enhanced properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drugs which often exhibit improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides, where the introduction of fluorine atoms can enhance biological activity and environmental persistence.
• Peptide Chemistry & Bioconjugation: Serves as an efficient acylating agent for modifying peptides, proteins, and other biomolecules, facilitating the creation of labeled probes or drug conjugates.
• Liquid Crystal & Polymer Precursor: Employed in the synthesis of fluorinated monomers and intermediates for high-performance polymers, liquid crystals, and specialty materials with unique thermal and chemical resistance.
• Cross-coupling Reagent: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures common in many functional materials.
• Derivatization Agent for Analytics: Used to derivative compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis, improving volatility and detection sensitivity.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenoxyacetyl Chloride
CAS No.	55502-53-9
Molecular Formula	C8H2ClF5O2
Molecular Weight	260.55 g/mol
Synonyms	Pentafluorophenoxyacetyl Chloride; 2,3,4,5,6-Pentafluorophenoxyacetic Acid Chloride; (Pentafluorophenoxy)acetyl Chloride; NSC 334908; Acetyl chloride, 2-(pentafluorophenoxy)-; α-Chloro-2,3,4,5,6-pentafluoroacetophenone (related structure); PFPOAC
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenoxyacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.