Description

2-Pyrrolidinecarbonyl Chloride, 5-Oxo- (9Ci) is a versatile and highly reactive organic intermediate, primarily used as a key building block in advanced chemical synthesis. Its value lies in its ability to efficiently introduce the 5-oxopyrrolidine-2-carbonyl moiety, a structural motif of significant interest in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of various drug candidates, including protease inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, contributing to novel modes of action.
• Peptide Mimetics & Prodrug Development: Employed to create peptide analogs and prodrug linkers, enhancing the stability and bioavailability of therapeutic agents.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialized polymers with unique properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses serving the biotechnology and pharmaceutical sectors.

Basic Information

Product Name	2-Pyrrolidinecarbonyl Chloride, 5-Oxo- (9Ci)
CAS No.	55478-53-0
Molecular Formula	C5H6ClNO2
Molecular Weight	147.56 g/mol
Synonyms	5-Oxopyrrolidine-2-carbonyl chloride; 2-Pyrrolidinecarbonyl chloride, 5-oxo-; L-Pyroglutamoyl chloride; (S)-5-Oxopyrrolidine-2-carbonyl chloride; Pyroglutamic acid chloride; 5-Oxo-D-proline chloride; Pyroglutamyl chloride; NSC 401024
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrrolidinecarbonyl Chloride, 5-Oxo- is produced and tested under stringent quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for advanced pharmaceutical intermediates, ensuring traceability and documentation excellence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.