Description

2'-o-Mb-Camp Sodium Salt is a chemically modified nucleotide analog, specifically a sodium salt derivative of a cyclic adenosine monophosphate (cAMP) molecule with a 2'-O-methylbutyryl (2'-o-Mb) substitution. This modification is critical for enhancing the compound's stability and membrane permeability in biological research applications. It serves as a vital research tool for scientists in pharmacology and molecular biology studying intracellular signaling pathways, particularly those mediated by protein kinase A (PKA). The product is essential for high-purity biochemical research, drug discovery, and the development of novel therapeutic agents targeting cyclic nucleotide signaling.

Application

• Biochemical Research: Used as a stable, cell-permeable analog of cAMP to activate Protein Kinase A (PKA) and study downstream signaling cascades in cell cultures.
• Drug Discovery & Development: Serves as a key reference standard and pharmacological tool in screening assays for compounds that modulate adenylate cyclase or phosphodiesterase activity.
• Cell Signaling Studies: Employed to investigate the role of cAMP in processes such as gene expression, metabolism, ion channel function, and cell proliferation/differentiation.
• Pharmaceutical Intermediates: Acts as a sophisticated synthetic intermediate in the research-scale production of more complex nucleotide-based therapeutics or probes.
• Academic & Institutional Research: Fundamental reagent for university and institutional labs exploring cardiovascular, neurological, and metabolic disorders linked to cyclic nucleotide pathways.

Basic Information

Product Name	2'-o-Mb-Camp Sodium Salt
CAS No.	55443-13-5
Molecular Formula	C20H24N5NaO7P
Molecular Weight	500.39 g/mol
Synonyms	2'-O-Monobutyryladenosine 3',5'-cyclic monophosphate sodium salt; 2'-O-MB-cAMP sodium salt; 2'-O-Butyryl-cAMP sodium salt; 2'-O-(α-Methylbutyryl)adenosine-3',5'-cyclic monophosphate sodium salt; Sodium 2'-O-(2-methylbutyryl)adenosine 3',5'-cyclic phosphate; 2'-O-(2-Methylbutyryl)-cAMP Na; 8-(4-Chlorophenylthio)-2'-O-methylbutyryl-cAMP sodium salt (common research analog); N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt (related compound)
EINECS	Contact for details

Quality Control

Our 2'-o-Mb-Camp Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for sensitive biological research. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with the expectations of GMP-grade facilities for non-therapeutic research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (Cell-based assay)	Activates PKA-dependent reporter gene expression (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.