Description

5-Hexynoyl Chloride is a versatile acid chloride derivative featuring a terminal alkyne functional group, making it a valuable bifunctional building block in organic synthesis. Its primary value lies in enabling the simultaneous introduction of an acyl group and an alkyne handle, facilitating efficient one-pot or sequential reactions for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for coupling reactions and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates via amide bond formation and click chemistry.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate alkyne motifs for enhanced biological activity.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and functionalized surfaces with tailored properties.
• Bioconjugation & Probe Development: Facilitates the labeling of biomolecules (proteins, peptides) and the creation of fluorescent or affinity probes for diagnostic and research applications.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation, esterification, and other nucleophilic acyl substitution reactions to install the 5-hexynoyl moiety.
• Ligand & Catalyst Preparation: Used to synthesize acetylene-functionalized ligands for metal-organic frameworks (MOFs) and homogeneous catalysis.

Basic Information

Product Name	5-Hexynoyl Chloride
CAS No.	55183-45-4
Molecular Formula	C6H7ClO
Molecular Weight	130.57 g/mol
Synonyms	Hex-5-ynoyl chloride; 5-Hexynoic acid chloride; 5-Hexynoyl chloride; 5-Hexynoic acid, chloride; 1-Pentyn-5-carboxylic acid chloride; 5-Hexynoylchloride; 5-Hexynoic acid chloride; 5-Hexynoylchlorid
EINECS	Contact for details

Quality Control

Our 5-Hexynoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and industrial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acid Chloride Content	≥ 96.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.