Description

[α-(Acetylamino)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group, making it a valuable synthetic intermediate. This compound is crucial for researchers and process chemists as it facilitates the controlled introduction of phosphonate functionality into target molecules, enabling the development of novel bioactive compounds and advanced materials. It is primarily needed by the pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry, catalyst development, and the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or requiring phosphate bioisosteres.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that utilize phosphonate chemistry.
• Ligand Synthesis: Serves as a precursor for creating sophisticated phosphonate-based ligands used in catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics: Employed in the construction of phosphonopeptides and other amino acid analogs for biochemical studies.
• Material Science: Intermediate for surface-modifying agents, flame retardants, and specialty polymers.
• Chemical Biology Probes: Useful in the design of activity-based probes and molecular tools for studying biological pathways.

Basic Information

Product Name	[α-(Acetylamino)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-86-6
Molecular Formula	C16H30NO4PSi2
Molecular Weight	387.56 g/mol
Synonyms	Bis(trimethylsilyl) [α-(acetylamino)phenethyl]phosphonate; N-[2-(Bis(trimethylsiloxy)phosphinyl)-1-phenylethyl]acetamide; Phosphonic acid, P-[2-(acetylamino)-1-phenylethyl]-, bis(trimethylsilyl) ester; (α-Acetamidophenethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Acetamide, N-[2-[bis(trimethylsiloxy)phosphinyl]-1-phenylethyl]-
EINECS	Contact for details

Quality Control

Our [α-(Acetylamino)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.