Description

[1-(Acetylamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group, making it a valuable synthetic intermediate. Its primary value lies in its role as a key building block for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. This compound is essential for researchers and manufacturers in the fine chemical, agrochemical, and life science industries who require high-purity, reactive intermediates for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate bioisosteres.
• Agrochemical Synthesis: Used in the development of advanced herbicides, plant growth regulators, and pesticides where the phosphonic acid moiety is critical for activity.
• Ligand and Catalyst Preparation: Acts as a starting material for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Employed in the development of surface modifiers, flame retardants, and specialty polymers requiring functional phosphonate groups.
• Peptide Mimetics: Useful in medicinal chemistry for incorporating hydrolytically stable phosphonate linkages into peptide analogs.
• Chemical Biology Probes: Facilitates the synthesis of activity-based probes and inhibitors for studying enzyme mechanisms, particularly phosphatases.

Basic Information

Product Name	[1-(Acetylamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-85-5
Molecular Formula	C12H28NO4PSi2
Molecular Weight	337.50 g/mol
Synonyms	Bis(trimethylsilyl) [1-(acetylamino)-2-methylpropyl]phosphonate; Phosphonic acid, P-[1-(acetylamino)-2-methylpropyl]-, bis(trimethylsilyl) ester; N-Acetyl-leucine phosphonic acid bis(trimethylsilyl) ester; (1-Acetamido-2-methylpropyl)phosphonic acid bis(trimethylsilyl) ester; TMS-protected leucine phosphonate; Ac-Leu(PO(OTMS)2); Leucine phosphonate bis-TMS ester
EINECS	Contact for details

Quality Control

Our production of [1-(Acetylamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.