Description

[1-(Acetylamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group, making it a valuable synthetic intermediate. This compound is critical for researchers and manufacturers requiring precise control over phosphonate chemistry in complex molecular construction. It is primarily utilized in the development of pharmaceuticals, agrochemicals, and advanced materials where its unique structure enables the introduction of phosphonate functionalities under mild conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting bone diseases, viral infections, or metabolic disorders via phosphonate-based prodrug strategies.
• Agrochemical Research: Used in creating advanced herbicides, plant growth regulators, or fungicides that incorporate phosphonate or phosphonic acid moieties for enhanced activity.
• Peptide Mimetics & Bioactive Molecule Synthesis: Serves as a precursor for phosphonopeptides and other bioactive analogs that mimic natural phosphate esters, useful in enzyme inhibition studies.
• Material Science Precursor: Employed in the development of specialty polymers, surface modifiers, or metal-chelating agents where the silyl-protected group allows for controlled deposition or reaction.
• Chemical Biology Probes: Facilitates the creation of labeled compounds or activity-based probes for studying biochemical pathways involving phosphorylation.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated phosphonate-containing ligands for asymmetric catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	[1-(Acetylamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-84-4
Molecular Formula	C13H32NO4PSi2
Molecular Weight	353.54 g/mol
Synonyms	Bis(trimethylsilyl) [1-(Acetylamino)pentyl]phosphonate; N-[1-(Bis(trimethylsilyloxy)phosphinyl)pentyl]acetamide; Phosphonic acid, [1-(acetylamino)pentyl]-, bis(trimethylsilyl) ester; Acetamide, N-[1-[bis(trimethylsilyloxy)phosphinyl]pentyl]-; 55108-84-4; [1-(Acetylamino)amyl]phosphonic Acid Bis(trimethylsilyl) Ester; TMS-protected Phosphonopeptide Derivative
EINECS	Contact for details

Quality Control

Our [1-(Acetylamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. For projects requiring specific grade qualifications, please contact our technical team to discuss custom synthesis and analytical protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.