Description

[1-(Acetylamino)Butyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a silyl-protected phosphonic acid group and an acetamido side chain. This molecular architecture makes it a valuable protected intermediate and key synthon in advanced organic synthesis, particularly for introducing phosphonate functionality under mild conditions. It is primarily utilized by pharmaceutical researchers and agrochemical developers engaged in the creation of novel bioactive molecules, including protease inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting enzymes like proteases and kinases.
• Agrochemical Research: Used in the development of new herbicides, plant growth regulators, and other crop protection agents with phosphonate activity.
• Peptide Mimetics Synthesis: Serves as a phosphonate-based transition state analog in the design of peptide mimetics and enzyme inhibitors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to introduce phosphonic acid motifs into lead compounds, modulating their bioavailability and potency.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and diagnostic agents for studying biological pathways.
• Organometallic Ligand Precursor: Acts as a precursor for ligands used in catalysis and material science applications.

Basic Information

Product Name	[1-(Acetylamino)Butyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-83-3
Molecular Formula	C13H32NO4PSi2
Molecular Weight	353.53 g/mol
Synonyms	N-Acetyl-1-aminobutylphosphonic Acid Bis(trimethylsilyl) Ester; (1-Acetamidobutyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[1-(acetylamino)butyl]-, bis(trimethylsilyl) ester; Bis(trimethylsilyl) [1-(Acetylamino)butyl]phosphonate; Acetamidobutylphosphonic Acid Bis-TMS Ester
EINECS	Contact for details

Quality Control

Our [1-(Acetylamino)Butyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.