Description

[1-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a silyl-protected phosphonic acid group and an acetamido moiety. This unique structure makes it a valuable protected intermediate and key building block in advanced organic synthesis, particularly for introducing phosphonate functionality under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require high-purity, reactive intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel bioactive molecules, including potential enzyme inhibitors and prodrugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators containing phosphonate groups.
• Ligand and Catalyst Preparation: Acts as a starting material for creating specialized phosphonate-based ligands used in catalysis and metal complexation.
• Peptide Mimetics and Prodrug Design: The protected phosphonic acid group is valuable for constructing phosphonate-containing amino acid analogs and prodrug candidates.
• Materials Science Research: Employed in the development of functionalized surfaces, metal-organic frameworks (MOFs), and novel polymeric materials.
• Chemical Biology Probes: Useful for synthesizing activity-based probes and molecular tools to study phosphonate-related biochemical pathways.

Basic Information

Item	Details
Product Name	[1-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-81-1
Molecular Formula	C11H28NO4PSi2
Molecular Weight	325.50 g/mol
Synonyms	1-(Acetylamino)propylphosphonic Acid Bis(trimethylsilyl) Ester; N-[1-(Bis(trimethylsilyloxy)phosphinyl)propyl]acetamide; (1-Acetamidopropyl)phosphonic Acid Bis(trimethylsilyl) Ester; APPA Bis(TMS) Ester; Phosphonic Acid, P-[1-(acetylamino)propyl]-, bis(trimethylsilyl) ester
EINECS	Contact for details

Quality Control

Our [1-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including NMR (¹H, ³¹P), HPLC, and Karl Fischer titration to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccated environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.