Description

[(Acetylamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a high-value organosilicon-protected phosphonate derivative, primarily used as a key synthetic intermediate. Its value lies in its role as a protected precursor for the introduction of phosphonic acid functional groups, which are crucial in the development of bioactive molecules and advanced materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors who require precise and stable building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a protected phosphonate synthon in the synthesis of nucleotide analogs, bisphosphonate drugs, and other bioactive compounds targeting bone diseases and viral infections.
• Agrochemical Research: Used in the development of novel herbicides, plant growth regulators, and fungicides that utilize phosphonate chemistry for enhanced activity and stability.
• Ligand and Catalyst Synthesis: Acts as a precursor for phosphonic acid-based ligands used in coordination chemistry, catalysis, and the preparation of metal-organic frameworks (MOFs).
• Material Science: Employed in the surface modification of materials, creation of self-assembled monolayers (SAMs), and development of corrosion inhibitors and flame retardants.
• Peptide Mimetics: Facilitates the incorporation of phosphonate groups into peptide backbones to create protease-resistant analogs for therapeutic and diagnostic applications.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and inhibitors for studying enzyme mechanisms, particularly phosphatases and kinases.

Basic Information

Product Name	[(Acetylamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-80-0
Molecular Formula	C11H28NO4PSi2
Molecular Weight	325.49 g/mol
Synonyms	N-[(Bis(trimethylsilyloxy)phosphinyl]methyl]acetamide; Phosphonic acid, P-[(acetylamino)methyl]-, bis(trimethylsilyl) ester; Acetamide, N-[(bis(trimethylsilyloxy)phosphinyl]methyl]-; (Acetamidomethyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected (Acetamidomethyl)phosphonate; Bis(trimethylsilyl) (Acetamidomethyl)phosphonate; (Acetylamino)methylphosphonic Acid Bis-O-(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our [(Acetylamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (¹H, ³¹P), and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.