Description

[1-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group and an imine functional group, making it a valuable intermediate in advanced organic synthesis. This compound is particularly significant for its role as a key building block in the preparation of complex molecules, including pharmaceuticals, agrochemicals, and novel materials. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, functionalized intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring phosphonate or aminophosphonate moieties for bioactivity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, pesticides, and plant growth regulators that utilize phosphonate chemistry.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized phosphine-based ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of functionalized polymers, surface modifiers, and flame retardants where phosphonate groups are incorporated.
• Peptide Mimetics and Prodrug Development: Utilized to introduce hydrolytically stable phosphonate isosteres into peptide backbones or to create prodrug forms of bioactive phosphonates.
• Chemical Biology Probes: Acts as a building block for creating activity-based probes and inhibitors for studying enzyme mechanisms, particularly those involving phosphate transfer.

Basic Information

Product Name	[1-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-73-1
Molecular Formula	C13H32NO3PSi2
Molecular Weight	337.55 g/mol
Synonyms	(1-((2,2-Dimethylpropylidene)amino)ethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[1-[(2,2-dimethylpropylidene)amino]ethyl]-, Bis(trimethylsilyl) Ester; (1-((Neopentylidene)amino)ethyl)phosphonic Acid Bis(TMS) Ester; Bis(trimethylsilyl) (1-((2,2-dimethylpropylidene)amino)ethyl)phosphonate; TMS-Protected (1-Aminoethyl)phosphonate Neopentylidene Derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our [1-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.