Description

4-Thiopseudouridine is a chemically modified nucleoside analog of pseudouridine, where the oxygen atom at the 4-position is replaced by sulfur. This structural modification is of significant interest in the development of novel therapeutic agents and research tools, particularly in the fields of antiviral and anticancer drug discovery. It serves as a critical building block for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on nucleoside chemistry and RNA biology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a probe to study RNA structure, function, and metabolism due to its modified nucleoside properties.
• Medicinal Chemistry: Serves as a building block for creating libraries of modified nucleosides to explore structure-activity relationships (SAR).
• Antiviral Drug Development: Investigated for its potential incorporation into oligonucleotides targeting viral replication mechanisms.
• RNA Therapeutics: Potential use in the synthesis of modified mRNA to enhance stability and translational efficiency for therapeutic applications.
• Academic & Contract Research: Essential reagent for universities and CROs conducting fundamental research in nucleic acid chemistry.

Basic Information

Product Name	4-Thiopseudouridine
CAS No.	55101-24-1
Molecular Formula	C9H12N2O5S
Molecular Weight	260.27 g/mol
Synonyms	4-Thio-ψ-uridine; 4-Thio-pseudouridine; 1-β-D-Ribofuranosyl-4-thiouracil; 4-Thio-5-ribosyluracil; 4-Thio-ψ; 4-S-Pseudouridine; 4-Thio-psi-uridine; 4-Thiouridine analog
EINECS	Contact for details

Quality Control

Our 4-Thiopseudouridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.