Description

(25R)-5α-Spirostan-12-One 1,2-Ethanediyl Acetal is a high-purity, specialized steroidal intermediate featuring a protected ketone functional group. This compound is critical for synthetic chemists requiring precise stereochemistry and functional group manipulation in complex organic synthesis. It is primarily utilized in the research and development of novel pharmaceutical agents, particularly in the synthesis of steroid-based drugs and bioactive natural product derivatives.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Research & Development: Used in academic and industrial R&D laboratories for exploring new synthetic pathways and creating novel chemical entities for biological screening.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex molecules, leveraging its acetal-protected carbonyl for selective reactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(25R)-5α-Spirostan-12-One 1,2-Ethanediyl Acetal
CAS No.	55028-80-3
Molecular Formula	C29H46O4
Molecular Weight	458.68 g/mol
Synonyms	(25R)-Spirostan-12-one, ethylene acetal; 12,12-Ethylenedioxy-(25R)-5α-spirostan; 5α-Spirostan-12-one, cyclic 1,2-ethanediyl acetal, (25R)-; 12,12-(Ethylenedioxy)-(25R)-5α-spirostan; (25R)-12,12-Ethylenedioxy-5α-spirostan; Steroidal ethylene ketal intermediate; 55028-80-3 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our (25R)-5α-Spirostan-12-One 1,2-Ethanediyl Acetal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (25R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.