Description

4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester is a high-value, protected intermediate in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex pharmaceutical molecules, particularly those targeting the central nervous system. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel analgesics, anesthetics, and other bioactive piperidine derivatives.

Application

• Pharmaceutical Intermediate: A crucial protected precursor in the multi-step synthesis of potent opioid receptor ligands and other pharmacologically active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) for pain management.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under controlled conditions in GMP or non-GMP environments.
• Academic & Industrial R&D: Employed in exploratory organic synthesis for constructing complex heterocyclic frameworks and studying silyl ester chemistry.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for analytical method development and quality control of related substances.

Basic Information

Product Name	4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester
CAS No.	54964-92-0
Molecular Formula	C15H23NO2Si
Molecular Weight	277.44 g/mol
Synonyms	4-Phenyl-4-piperidinecarboxylic acid TMS ester; 4-Carboxy-4-phenylpiperidine trimethylsilyl ester; Trimethylsilyl 4-phenylisonipecotate; 4-Phenylpiperidine-4-carboxylic acid trimethylsilyl ester; 1,1-Dimethylethyl 4-phenyl-4-piperidinecarboxylate (related Boc-protected analog); 4-Phenyl-4-(trimethylsilyloxycarbonyl)piperidine; TMS ester of 4-phenyl-4-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.