Description

19-Norcortisol is a key synthetic steroid intermediate with significant importance in pharmaceutical research and development. This compound serves as a crucial building block for the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel corticosteroids and other therapeutic agents. The product, identified by CAS NO 54947-44-3, is supplied to meet the stringent purity and consistency requirements of advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of advanced corticosteroid drugs and other steroid-based therapeutics.
• Research & Development: Used in medicinal chemistry labs for structure-activity relationship (SAR) studies and the development of new steroid analogs with potential biological activity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Process Chemistry: Integral to scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for steroid APIs.
• Biochemical Research: Utilized in studies investigating steroid hormone metabolism, receptor binding, and enzymatic pathways.

Basic Information

Product Name	19-Norcortisol
CAS No.	54947-44-3
Molecular Formula	C₂₀H₂₈O₅
Molecular Weight	348.43 g/mol
Synonyms	11β,17,21-Trihydroxy-19-norpregn-4-ene-3,20-dione; 19-Norhydrocortisone; 19-Nor-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; 19-Norcortisol; 19-Nor Compound F
EINECS	Contact for details

Quality Control

Our 19-Norcortisol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents. We adhere to cGMP principles where applicable to support our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.