Description

5'-O-tert-Butyldimethylsilyluridine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides and nucleotide analogs. This compound provides a robust and selective protecting group for the 5'-hydroxyl position, enabling complex multi-step synthetic sequences in research and development. It is a critical building block for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the development of novel therapeutics, including antisense oligonucleotides, siRNA, and antiviral agents.

Application

• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of DNA and RNA sequences.
• Antiviral Drug Development: Used as a key intermediate in the research and production of nucleoside-based antiviral prodrugs.
• Medicinal Chemistry Research: Acts as a versatile building block for creating modified nucleosides with tailored biological activity.
• siRNA and Antisense Technology: Critical for the preparation of modified siRNA strands to enhance stability and efficacy.
• Bioconjugation: Facilitates the site-specific labeling or functionalization of nucleic acids for diagnostic applications.
• Process Chemistry & Scale-up: Employed in the development of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-O-tert-Butyldimethylsilyluridine
CAS No.	54925-65-4
Molecular Formula	C15H26N2O6Si
Molecular Weight	358.47 g/mol
Synonyms	5'-O-TBDMS-uridine; 5'-O-(tert-Butyldimethylsilyl)uridine; Uridine, 5'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione; TBDMS-Uridine; 5'-TBDMS-Urd
EINECS	Contact for details

Quality Control

Our 5'-O-tert-Butyldimethylsilyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.