Description

3,3′,5-Triiodo-L-Thyronine Methyl Ester is a chemically modified derivative of the thyroid hormone triiodothyronine (T3), designed for enhanced stability and specific research applications. This compound is a critical intermediate and reference standard in the development and analysis of thyroid hormone analogs and metabolic regulators. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on endocrinology and metabolic disease research.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quantifying thyroid hormones and their metabolites.
• Biochemical Research: Serves as a key intermediate in the synthesis of novel thyroid hormone receptor (TR) agonists and antagonists for metabolic studies.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo research to investigate the mechanisms of thyroid hormone action, gene expression, and energy homeostasis.
• Diagnostic Kit Development: Acts as a critical component in the formulation and quality control of immunoassays and diagnostic tests for thyroid function.
• Academic & Institutional Research: Provides a stable, well-defined chemical tool for universities and research institutes studying endocrinology and hormone signaling pathways.

Basic Information

Item	Details
Product Name	3,3′,5-Triiodo-L-Thyronine Methyl Ester
CAS No.	54914-53-3
Molecular Formula	C16H13I3NO4
Molecular Weight	688.99 g/mol
Synonyms	L-T3 Methyl Ester; Liothyronine Methyl Ester; 3,3',5-Triiodothyronine Methyl Ester; T3 Methyl Ester; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine Methyl Ester; Methyl 3,3',5-triiodo-L-thyroninate; (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3,3′,5-Triiodo-L-Thyronine Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. Quality is verified through comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.