Description

8-Hydroxymethyl Guanosine is a modified nucleoside derivative of guanosine, featuring a hydroxymethyl group at the 8-position of the purine ring. This structural modification makes it a valuable intermediate and reference standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications in nucleotide chemistry, antiviral research, and as a building block for novel therapeutic agents.

Application

• Biochemical Research Intermediate: Serves as a key synthetic precursor for the study of modified nucleotides and nucleic acid analogs.
• Pharmaceutical Reference Standard: Used as a high-purity standard in analytical methods for quality control of nucleoside-based APIs and related compounds.
• Antiviral Drug Development: Investigated as a potential building block or active moiety in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Enzymology Studies: Employed in studies of enzyme kinetics and mechanisms involving nucleotide modification and recognition.
• Diagnostic Reagent Component: Can be used in the formulation of specialized reagents for molecular diagnostics and research kits.

Basic Information

Product Name	8-Hydroxymethyl Guanosine
CAS No.	54898-41-8
Molecular Formula	C11H15N5O6
Molecular Weight	313.27 g/mol
Synonyms	8-(Hydroxymethyl)guanosine; Guanosine, 8-(hydroxymethyl)-; 8-HMG; 8-Hydroxymethylguanosine; 8-(Hydroxymethyl)-9H-purin-6-amine, 9-β-D-ribofuranosyl-; 9-β-D-Ribofuranosyl-8-(hydroxymethyl)guanine
EINECS	Contact for details

Quality Control

Our 8-Hydroxymethyl Guanosine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.