Description

Mitonafide CAS NO 54824-17-8 is a synthetic organic compound belonging to the class of naphthalimides, recognized for its significant biological activity. This compound is of primary interest to the pharmaceutical research and development sector due to its established role as a DNA intercalating agent and topoisomerase II inhibitor. It is a critical intermediate and reference standard for researchers developing novel chemotherapeutic agents and studying mechanisms of anticancer activity.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anticancer therapies.
• Biochemical Research: Used as a potent tool compound to study DNA interaction mechanisms, topoisomerase II inhibition, and apoptosis induction in cancer cell lines.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and toxicology profiles.
• Chemical Synthesis: Acts as a versatile building block for the synthesis of more complex naphthalimide derivatives with potential enhanced activity or reduced toxicity.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and molecular pharmacology.

Basic Information

Product Name	Mitonafide
CAS No.	54824-17-8
Molecular Formula	C₁₉H₁₇N₃O₃
Molecular Weight	335.36 g/mol
Synonyms	3-Nitro-6-(2-dimethylaminoethyl)-1H-benz[de]isoquinoline-1,3(2H)-dione; Amonafide; 6-[(2-Dimethylamino)ethyl]-3-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione; Nafidimide; NSC-308847; UNII-3Y7UJK5P8F; Benzo[de]isoquinoline-1,3-dione, 6-[(2-(dimethylamino)ethyl]-3-nitro-
EINECS	Contact for details

Quality Control

Our Mitonafide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.