Description

1,2,3-Thiadiazole-5-Carbonyl Chloride (9Ci) is a versatile and highly reactive heterocyclic building block, essential for constructing complex molecular architectures. Its core value lies in its ability to introduce the 1,2,3-thiadiazole moiety, a privileged scaffold known for imparting significant biological activity in pharmaceuticals and agrochemicals. This intermediate is critically needed by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in antiviral, antibacterial, and anticancer research programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the thiadiazole ring enhances efficacy.
• Material Science Research: Serves as a precursor for functional polymers and advanced materials with specific electronic or photophysical properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers producing bespoke compounds for client R&D.

Basic Information

Product Name	1,2,3-Thiadiazole-5-Carbonyl Chloride (9Ci)
CAS No.	54742-57-3
Molecular Formula	C3HN2OSCl
Molecular Weight	148.57 g/mol
Synonyms	1,2,3-Thiadiazole-5-carbonyl chloride; 1,2,3-Thiadiazole-5-carboxylic acid chloride; 5-Chlorocarbonyl-1,2,3-thiadiazole; Thiadiazole-5-carbonyl chloride; 1,2,3-Thiadiazole-5-carboxylic chloride; 5-Carboxy-1,2,3-thiadiazole chloride; 1,2,3-Thiadiazole-5-COCl
EINECS	Contact for details

Quality Control

Our 1,2,3-Thiadiazole-5-Carbonyl Chloride is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and handled under dry conditions to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.