Description

2,3-Dihydro-1H-Indene-2-Carbonyl Chloride is a versatile and highly reactive acid chloride derivative of indane. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the 2,3-dihydro-1H-indene-2-carbonyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the indane scaffold contributes to biological activity.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Peptide Mimetics: Employed to create conformationally constrained peptide analogs and protease inhibitors in medicinal chemistry.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to tag or modify biomolecules for studying biological pathways and protein function.

Basic Information

Product Name	2,3-Dihydro-1H-Indene-2-Carbonyl Chloride
CAS No.	54672-55-8
Molecular Formula	C10H9ClO
Molecular Weight	180.63 g/mol
Synonyms	Indane-2-carbonyl chloride; 2-Indanecarbonyl chloride; 2,3-Dihydro-1H-indene-2-carboxylic acid chloride; 2-Carboxyindane chloride; Hydrindene-2-carbonyl chloride; 2-(Chlorocarbonyl)indane; 1,2,3,4-Tetrahydro-2-naphthoyl chloride (related); 54672-55-8
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-1H-Indene-2-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.