Description

22(R)-Hydroxydesmosterol is a high-purity, stereospecific oxysterol derivative of desmosterol. This compound serves as a critical reference standard and biochemical research tool for investigating cholesterol biosynthesis, lipid metabolism, and related signaling pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on metabolic disorders and neurodegenerative diseases.

Application

• Biochemical Research: Used as a key intermediate or reference standard in studies of the cholesterol biosynthesis pathway, specifically the Bloch and Kandutsch-Russell pathways.
• Pharmaceutical R&D: Serves as a precursor or analytical standard in the development of therapeutics targeting lipid metabolism, such as for atherosclerosis or Alzheimer's disease.
• Cell Biology Studies: Employed to investigate the biological activity of specific oxysterols on cell differentiation, proliferation, and apoptosis.
• Analytical Chemistry: Functions as a high-purity certified reference material (CRM) for method development and validation in HPLC, LC-MS, or GC-MS analyses.
• Enzymology: Used as a substrate to study the activity and inhibition of enzymes like sterol reductases or hydroxylases involved in sterol metabolism.

Basic Information

Product Name	22(R)-Hydroxydesmosterol
CAS No.	54604-98-7
Molecular Formula	C27H44O2
Molecular Weight	400.64 g/mol
Synonyms	(22R)-22-Hydroxycholesta-5,24-dien-3β-ol; 22R-Hydroxydesmosterol; (3β,22R)-Cholesta-5,24-diene-3,22-diol; 22-Hydroxydesmosterol; Desmosterol, 22-hydroxy-; 22(R)-OH-Desmosterol; 22R-Hydroxy-5,24-cholestadien-3β-ol
EINECS	Contact for details

Quality Control

We supply 22(R)-Hydroxydesmosterol as a high-purity material suitable for research and development. Our products undergo rigorous quality testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing analytical results from techniques such as HPLC, NMR, and MS. We adhere to strict in-house quality standards to meet the demands of critical scientific applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Purity (Titration)	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.