Description

5-Bromo-2',3'-o-Isopropylideneuridine is a key protected nucleoside intermediate, specifically a brominated derivative of uridine with an isopropylidene group protecting the 2' and 3' hydroxyls. This compound is critical for synthetic organic and medicinal chemists as it provides a reactive handle for further functionalization while maintaining the integrity of the ribose sugar moiety. It is primarily utilized in the research and development of novel antiviral agents, modified oligonucleotides, and other bioactive nucleoside analogs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of antiviral and anticancer nucleoside prodrugs.
• Oligonucleotide Synthesis: Used for the preparation of modified RNA and DNA sequences for research and therapeutic applications.
• Medicinal Chemistry Research: Serves as a versatile precursor for structure-activity relationship (SAR) studies in drug discovery programs.
• Bioconjugation: The bromo group allows for cross-coupling reactions, enabling the attachment of fluorophores, targeting ligands, or other functional groups.
• Academic & Industrial R&D: Fundamental research tool in biochemistry and molecular biology for studying nucleic acid interactions and enzyme mechanisms.

Basic Information

Item	Details
Product Name	5-Bromo-2',3'-o-Isopropylideneuridine
CAS No.	54503-61-6
Molecular Formula	C12H15BrN2O6
Molecular Weight	363.16 g/mol
Synonyms	5-Bromo-2',3'-O-isopropylideneuridine; 5-Br-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-5-bromouridine; 5-Bromouridine 2',3'-acetonide; Uridine, 5-bromo-2',3'-O-(1-methylethylidene)-; 5-Bromo-2',3'-O-(1-methylethylidene)uridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2',3'-o-Isopropylideneuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.