Description

Spiro[5α-Cholestane-3,2'-[1,3]Dioxolane]-2β-Carboxylic Acid Methyl Ester is a high-purity, steroidal derivative characterized by its unique spirocyclic dioxolane structure. This compound is a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, valued for its defined stereochemistry and functional group compatibility. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of novel therapeutic agents and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of steroidal drugs and hormone-based therapies.
• Organic Synthesis Building Block: Used in the construction of complex natural products and bioactive molecules due to its rigid spirocyclic framework.
• Chemical Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating sterol metabolism, membrane biophysics, and receptor-ligand interactions.
• Material Science Precursor: Potential use in the synthesis of specialized liquid crystals or advanced organic materials with specific stereochemical properties.

Basic Information

Product Name	Spiro[5α-Cholestane-3,2'-[1,3]Dioxolane]-2β-Carboxylic Acid Methyl Ester
CAS No.	54498-63-4
Molecular Formula	C₃₁H₅₀O₄
Molecular Weight	490.73 g/mol
Synonyms	Methyl 2β-(Spiro[1,3]dioxolane-2,3'-5α-cholestane)-carboxylate; 2β-Carbomethoxy-3α,5-cyclo-5α-cholestane-3-spiro-2'-(1',3'-dioxolane); 5α-Cholestane-3-spiro-2'-(1',3'-dioxolane)-2β-carboxylic Acid Methyl Ester; Spirocholestane Dioxolane Methyl Ester; (2β,3α,5α)-3-Spiro(1,3-dioxolan-2-yl)cholestane-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Spiro[5α-Cholestane-3,2'-[1,3]Dioxolane]-2β-Carboxylic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.