Description

Cyclohexanecarbonyl Chloride, 2,2,6,6-Tetramethyl- (9Ci) is a specialized, sterically hindered acid chloride derivative of pivalic acid, offering a unique combination of high reactivity and stability for advanced synthetic chemistry. Its value lies in its role as a key building block for introducing the bulky, lipophilic 2,2,6,6-tetramethylcyclohexanoyl moiety, which can significantly alter the physical and biological properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular modifications to develop new active ingredients or functional materials.

Application

• Pharmaceutical Intermediates: A crucial reagent for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of prodrugs or compounds where steric bulk is needed to modulate metabolism, bioavailability, or receptor binding.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the tetramethylcyclohexane structure can enhance lipophilicity and environmental stability.
• Polymer Science & Advanced Materials: Serves as a monomer or modifying agent for creating specialty polymers with tailored properties such as increased thermal stability, specific solubility, or unique surface characteristics.
• Ligand & Catalyst Development: Employed in organic and organometallic chemistry to synthesize novel ligands and catalysts, where the steric hindrance can control selectivity and reactivity in catalytic cycles.
• Fine Chemical & Dye Manufacturing: Acts as an acylating agent in the synthesis of complex dyes, pigments, and other high-value fine chemicals requiring specific steric profiles.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new chemical entities and conducting structure-activity relationship (SAR) studies.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 2,2,6,6-Tetramethyl- (9Ci)
CAS No.	54439-96-2
Molecular Formula	C11H19ClO
Molecular Weight	202.72 g/mol
Synonyms	2,2,6,6-Tetramethylcyclohexanecarbonyl Chloride; 2,2,6,6-Tetramethylcyclohexane-1-carbonyl Chloride; TMCH-COCl; Tetramethylcyclohexanoyl Chloride; Perhydro-2,2,6,6-tetramethyl-1-naphthoic Acid Chloride; 1-Chlorocarbonyl-2,2,6,6-tetramethylcyclohexane; 2,2,6,6-Tetramethyl-1-cyclohexanecarboxylic Acid Chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 2,2,6,6-Tetramethyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.