Description

5-Fluoro-2'-Deoxyuridine 5'-(p-Amino*Phe Nyl) Monoph is a chemically modified nucleoside monophosphate analog, a key intermediate in the development of targeted therapeutic agents and diagnostic tools. This compound is valued for its role in creating prodrugs and conjugates, particularly in the field of oncology and antiviral research, where precise biochemical targeting is critical. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleotide-based drug discovery and molecular biology.

Application

• Anticancer Prodrug Development: Serves as a critical building block for synthesizing enzyme-activated prodrugs in antibody-directed enzyme prodrug therapy (ADEPT) and other targeted cancer treatment strategies.
• Antiviral Research: Used in the research and development of nucleotide analogs designed to inhibit viral replication mechanisms.
• Biochemical Conjugation: The p-aminophenyl moiety facilitates conjugation to antibodies, peptides, or other targeting vectors for creating site-specific drug delivery systems.
• Enzyme Substrate Studies: Employed as a substrate to study the activity and kinetics of specific enzymes, such as thymidine phosphorylase, in biochemical assays.
• Radiopharmaceutical Precursor: Acts as a precursor for the synthesis of compounds labeled with radioactive isotopes for diagnostic imaging or targeted radiotherapy.
• Academic & Pharmaceutical R&D: A vital tool in basic research exploring nucleotide metabolism and in the discovery pipeline for novel therapeutic entities.

Basic Information

Product Name	5-Fluoro-2'-Deoxyuridine 5'-(p-Amino*Phe Nyl) Monoph
CAS No.	54397-88-5
Molecular Formula	C16H19FN3O8P
Molecular Weight	431.31 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine 5'-(p-aminophenyl) monophosphate; 5-FdUrd-5'-P-AP; 5-Fluoro-2'-deoxyuridylyl-(5'→N)-p-aminobenzene; p-Aminophenyl 5-fluoro-2'-deoxyuridine 5'-monophosphate; 5-Fluoro-2'-deoxyuridine 5'-(4-aminophenyl) phosphate; 5-FdUMP-AP; FDURD-P-AP; Targeted 5-FdUMP prodrug intermediate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2'-Deoxyuridine 5'-(p-Amino*Phe Nyl) Monoph is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture should be avoided to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.