Description

5B-Pregnan-20A-Ol-3-One is a high-purity steroid intermediate, also known as 5β-Pregnan-3α-ol-20-one, with the CAS number 54353-11-6. This compound is a critical building block in the synthesis of various pharmaceutical steroids and hormones, valued for its defined stereochemistry and purity. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on steroid-based therapeutics, including corticosteroids and neurosteroids.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of corticosteroid drugs and other therapeutic steroid molecules.
• Neurosteroid Research: Used in the study and development of neuroactive steroids that modulate neurotransmitter receptors.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Biochemical Research: Employed in metabolic pathway studies and enzymatic conversion experiments related to steroidogenesis.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis to create more complex steroid derivatives with specific biological activity.

Basic Information

Product Name	5B-Pregnan-20A-Ol-3-One
CAS No.	54353-11-6
Molecular Formula	C21H34O2
Molecular Weight	318.50 g/mol
Synonyms	5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; Allopregnan-3α-ol-20-one; 5β-Pregnane-3α,20α-diol-20-one; Pregnanolone (specific isomer); 5β-DHP; Tetrahydroprogesterone (5β-isomer); 5β-Pregnan-20α-ol-3-one
EINECS	Contact for details

Quality Control

Our 5B-Pregnan-20A-Ol-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.